J Maxillofac Oral Surg. 2015 Jun;14(2):171-5. doi: 10.1007/s12663-014-0641-9. Epub 2014 Sep 4.
Botulinum toxin in the treatment of muscle specific Oro-facial pain: a literature review.
Sunil Dutt C1, Ramnani P1, Thakur D1, Pandit M1.
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Abstract
Facial pain associated with temporomandibular joint (TMJ) and surrounding structures has been a challenge to clinicians as far as diagnosis and management is concerned. Complexity of anatomical structures within a small area, function of teeth and surrounding periodontal ligament, action of muscles, pathologies, lack of diagnostic investigations, all these complicate specific diagnosis of TMJ disorders. Various classifications have been designed and studied to help diagnose and treat TMJ related disorders, of which the simplest one is pain from TMJ proper and surrounding muscles. Many treatment modalities to treat pain arising from muscles around TMJ like splints, mouth restriction exercises, injection of sclerosing agents etc. have been used with various degrees of success. Botulinum toxin has been shown to be effective in the treatment of oro-facial pain due to muscular disorders and the same is discussed in detail in this review literature.

Int J Oral Maxillofac Surg. 2013 Jun;42(6):759-64. doi: 10.1016/j.ijom.2013.02.009. Epub 2013 Mar 26.
Botulinum toxin injection for management of temporomandibular joint clicking.
Emara AS1, Faramawey MI, Hassaan MA, Hakam MM.
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Abstract
The aim of the present study was to investigate the effect of botulinum toxin type A (BTX-A) injection in the lateral pterygoid (LP) muscle on temporomandibular joint (TMJ) clicking. The study enrolled seven patients with a total of 11 joints; all patients were stage I or II of Wilke's staging for internal derangement. BTX-A was injected in the ipsilateral LP muscle with electromyogram (EMG) guidance and the subjects were assessed for 4 months. Maximum inter-incisal opening, range of lateral movement, and the presence of a click were recorded throughout the follow-up period, and magnetic resonance imaging (MRI) was ordered at the end of the 4 months. The results showed that the decrease in inter-incisal opening and side to side movement immediately postoperative was statistically significant, while the difference by the end of the follow-up period was insignificant. MRI showed a marked improvement in disc position postoperatively. It may be concluded that BTX injection in the LP muscle leads to the disappearance of joint clicking clinically and a significant improvement in disc position as shown on MRI.
Copyright © 2013 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Rev Stomatol Chir Maxillofac. 2012 Feb;113(1):27-31. doi: 10.1016/j.stomax.2011.12.003. Epub 2012 Jan 10.
[Botulinum toxin A: analgesic treatment for temporomandibular joint disorders].
[Article in French]
Denglehem C1, Maes JM, Raoul G, Ferri J.
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Abstract
INTRODUCTION:
Pain, along with clicking, sub-luxation, and blocking, is one of the main symptoms for patients presenting with temporomandibular joint disorders. We assessed the effectiveness of botulinum toxin A (BOTOX(®), Allergan) as analgesic treatment for temporomandibular joint disorders.
PATIENTS AND METHOD:
Twenty-six patients with chronic pain linked to temporomandibular joint disorders were prospectively assessed. Botulinum toxin A was injected in masseter and temporalis muscles. Follow-up parameters, at one and three months, were: measuring mouth opening and diduction, muscle tenderness and pain using a visual analogue scale.
RESULTS:
There was a significant (P<0.0001) decrease of pain, an increased mouth opening, and diduction at three months. Seventy percent of the patients felt less muscle tenderness. The patient felt his psychological state had improved and so did his family.
DISCUSSION:
Botulinum toxin A significantly decreases pain and improves movements of patients presenting with temporomandibular joint disorders. The effects are prolonged three months after the injection.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Dent Update. 2006 Apr;33(3):165-8.
A review of the current uses of Botox for dentally-related procedures.
Bhogal PS1, Hutton A, Monaghan A.
Author information
Abstract
Botox is the most widely used abbreviation for botulinum toxin type A (BtA). This drug has received wide coverage in the press and media for its cosmetic advantages, especially in the facial region. The clinician may be aware of the many courses becoming available and aimed at dentists to start using it in the cosmetic context. This paper intends to provide a basic understanding of the many functional uses of the drug in the orofacial region that may be relevant to everyday practice.
CLINICAL RELEVANCE:
Awareness of the current medical, as opposed to purely cosmetic, uses of botulinum toxin in the orofacial region is desirable and this paper should inform clinicians and their patients with respect to this increasingly popular drug.

Int J Oral Maxillofac Surg. 2017 Mar;46(3):322-327.
Clinical outcomes of Botox injections for chronic temporomandibular disorders: do we understand how Botox works on muscle, pain, and the brain?
Connelly ST1, Myung J2, Gupta R2, Tartaglia GM3, Gizdulich A3, Yang J4, Silva R2